Does the gut hold the key to prevention? Targeting specific microbiota in the gut could be one way to protect against type 1 diabetes, a new study concludes. Researchers from the University of Queensland in Australia have found distinct gut microbiota alterations in rodents and humans that are at high risk of type 1 diabetes. […]
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Lovers’ heartbeats and respiration patterns tend to synchronize when the partners are simply in each other’s presence. But what does the role of touch play in this synchronization, and what happens when one of the partners is experiencing pain? Have you ever noticed that when you walk alongside your partner, your steps tend to synchronize? […]
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Does the gut hold the key to prevention? Targeting specific microbiota in the gut could be one way to protect against type 1 diabetes, a new study concludes. Researchers from the University of Queensland in Australia have found distinct gut microbiota alterations in rodents and humans that are at high risk of type 1 diabetes. […]
https://moreliaclinic.com/wp-content/uploads/2015/08/FINAL-MORELIA-LOGO1.png00adminhttps://moreliaclinic.com/wp-content/uploads/2015/08/FINAL-MORELIA-LOGO1.pngadmin2018-02-20 20:58:272018-02-20 20:58:27Prevention of Type 1 diabetes.
Lovers’ heartbeats and respiration patterns tend to synchronize when the partners are simply in each other’s presence. But what does the role of touch play in this synchronization, and what happens when one of the partners is experiencing pain? Have you ever noticed that when you walk alongside your partner, your steps tend to synchronize? […]
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Targeting specific microbiota in the gut could be one way to protect against type 1 diabetes, a new study concludes.
Researchers from the University of Queensland in Australia have found distinct gut microbiota alterations in rodents and humans that are at high risk of type 1 diabetes.
Furthermore, the scientists found that these gut microbiota alterations were a result of genetic susceptibility to type 1 diabetes, as well as changes in immune system functioning.
Researchers findings suggest that targeting the gut microbiota might have the potential to prevent type 1 diabetes.
In type 1 diabetes, the immune system mistakingly attacks and destroys the beta cells, or those that produce insulin, of the pancreas. As a result, not enough insulin is made, and this can lead to an increase in blood sugar levels.
Type 1 diabetes accounts for around 5 percent of all diabetes cases, and onset of the condition is most common in childhood, adolescence, and young adulthood.
Type 1 diabetes and the gut
Although the precise cause of type 1 diabetes remains unclear, it is known that those who possess certain genetic variants are at greater risk of the condition.
For example, susceptibility to type 1 diabetes is higher among individuals who have variants of the human leukocyte antigen complex, such as the HLA-DQA1, HLA-DQB1, and HLA-DRB1 genes. These are genes that play a role in immune system functioning.
Research also suggested that changes in gut microbiota — or the population of microorganisms that reside in the intestine — play a role in the development of type 1 diabetes.
However it is unclear whether such changes in gut microbiota are driven by genetic susceptibility to type 1 diabetes or other factors. The team sought to find out with the new study.
First, they conducted an analysis of non-obese mouse models that were genetically susceptible to type 1 diabetes. They looked at whether the rodents’ gut microbiota differed to that of mice that were protected against type 1 diabetes, and, if so, whether genetic susceptibility played a role.
The results of the analysis revealed that the mouse models with genetic susceptibility to type 1 diabetes demonstrated alterations in gut microbiota composition. Specifically, they showed reductions in Ruminococcus, Lachnospiraceae, and Clostridiales bacteria.
What is more, the scientists found that these alterations were associated with changes in immune system functioning.
The study also found that using immunotherapy to target T cells — which are a type of white blood cell — related to type 1 diabetes led to significant changes in the gut microbiota of rodents.
A route for prevention?
The researchers were able to confirm their findings in a study of humans with genetic susceptibility to type 1 diabetes.
Researchers now plan to assess clinical trials of immunotherapies for type 1 diabetes, with the aim of finding out whether the treatment led to changes in gut microbiota.
If so, the researchers say that it could then be possible to protect against type 1 diabetes by restoring protective gut microorganisms.
“This research has show there is a genetic component to microbiota and the immune response involved in regulating it. This means that changes in the microbiota in type 1 diabetes occur before symptoms develop, and are not just a side effect of the disease.
Therapies targeting the microbiota could therefore have the potential to help prevent type 1 diabetes in the future.
Woman Performing Blood Test on Herself
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Lovers’ heartbeats and respiration patterns tend to synchronize when the partners are simply in each other’s presence. But what does the role of touch play in this synchronization, and what happens when one of the partners is experiencing pain?
Have you ever noticed that when you walk alongside your partner, your steps tend to synchronize? Or that when you speak to a close friend, you tend to adopt the same posture as them?
The scientific name for this is “behavioral synchrony,” and it refers to the human ability to synch up with other people for the sake of living in a society.
Some studies have shown that people are not only able to synchronize their behavior, but that they can also sync up their physiology.
“Interpersonal synchronization” can manifest in various ways. For example, when people watch the same movie, their brain activity synchronizes. Similarly, when lovers stare into each other’s eyes, their hearts quite literally beat as one.
New research carried out by scientists at University of Colorado (CU) Boulder explores the role of touch in driving interpersonal synchronization in the context of pain.
The team was led by Pavel Goldstein, a postdoctoral pain researcher in the Cognitive and Affective Neuroscience Lab at CU Boulder, and the findings were published in the journal Scientific Reports.
Studying pain and touch in couples
Dr. Goldstein and colleagues gathered 22 heterosexual couples for their study, who were all aged between 23 and 32.
The researchers asked the couples to participate in a range of tests that replicated the experience of being in a delivery room.
The female participants were assigned the role of “pain receiver,” while the men were “pain observers.”
Dr. Goldstein and team recorded the participants’ respiration rates and heartbeats using an electrocardiogram under both pain and no pain conditions, as well as in both touch and no touch conditions.
Under the no pain condition, the couples either sat together without touching, sat together while holding hands, or were in separate rooms. In the pain scenario, all three situations were repeated, but the woman was subjected to “mild heat pain” for 2 minutes.
Touch restores synchronicity, eases pain
The study confirmed previous findings and showed that couples do synchronize physiologically just by being in each other’s company.
When the woman was subjected to pain and her partner did not touch her, that physiological coupling was considerably diminished. However, when the male partner held her hand, heart rates and respiration rates synched up again, and the woman’s pain was reduced. Additionally, holding hands increased the male partner’s empathy.
Overall, touch seems to play a key role in interpersonal synchronization, as it increased physiological coupling regardless of whether the woman was in pain or not.
This confirms Dr. Goldstein’s previous research, in which he showed that the more empathetic a man is toward a woman, the less pain the woman feels.
It appears that the more physiologically synched we are, the more our pain subsides. However, the researchers do not know whether lower-intensity pain increases interpersonal synchronicity, or whether it is the other way around.
“It could be that touch is a tool for communicating empathy, resulting in an analgesic, or pain-killing, effect,” Dr. Goldstein says. Interpersonal coupling may also enhance the analgesic effects of touch using the autonomic nervous system, the authors hypothesize.
Dr. Goldstein also supposes that interpersonal synchronization may affect a brain region called the anterior cingulate cortex, which has been associated with decision-making, social interactions, pain perception both in oneself and in others, and empathy.
But more research is needed, he concedes, to understand the precise mechanism by which a partner’s touch helps to diminish pain.
Limitations of the study include the fact that it did not examine same-sex couples or the effect of touch on men experiencing pain.
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